MSRseq enables the goals of the National Academies
Featured Article
"There is a critical need in the field to improve … methodologies for enhancing capabilities for sequencing RNA modifications and determining their abundance and stoichiometry. " (Pg. 5)
Additional Publications
Analysis of queuosine and 2-thio tRNA modifications by high throughput sequencing
https://pubmed.ncbi.nlm.nih.gov/35713550/A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation
https://www.nature.com/articles/s41467-022-30261-3
Profiling Selective Packaging of Host RNA and Viral RNA Modification in SARS-CoV-2 Viral Preparations
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851031/tRNA abundance, modification and fragmentation in nasopharyngeal swabs as biomarkers for COVID-19 severity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664364/Single-read tRNA-seq analysis reveals coordination of tRNA modification and aminoacylation and fragmentation
https://pubmed.ncbi.nlm.nih.gov/36537222/Design, construction, and functional characterization of a tRNA neochromosome in yeast
https://pubmed.ncbi.nlm.nih.gov/37944512/
Engineered mischarged transfer RNAs for correcting pathogenic missense mutations
https://pubmed.ncbi.nlm.nih.gov/38104240/Prokaryotic RNA N1-Methyladenosine Erasers Maintain tRNA m1A Modification Levels in Streptomyces venezuelae
https://pubmed.ncbi.nlm.nih.gov/38912606/Modifications in the T arm of tRNA globally determine tRNA maturation, function, and cellular fitness
https://www.pnas.org/doi/abs/10.1073/pnas.2401154121